Santiago de Chile is Chile's capital and, when viewed as a conurbation (Greater Santiago), its largest city. It is situated at an elevation of 520 m (1700 ft) in the country's central valley. Although Santiago is the capital, legislative bodies meet in nearby Valparaíso.

Approximately two decades of uninterrupted economic growth have transformed Santiago into one of Latin America's most sophisticated metropolitan areas, with extensive suburban development, dozens of shopping malls, and impressive high-rise architecture. The city also boasts some of Latin America's most spectacular infrastructure, such as the Santiago Metro and the sparkling new Costanera Norte, a freeway system that passes below downtown and connects the Eastern and Western extremes of the city in 15 minutes. Santiago is headquarters to many important companies and is a regionally important financial center.

The Palacio de La Moneda (built in 1784) is the present seat of the President of the Republic. It is one of the most notable buildings constructed by the Spanish crown in its American colonies. It is located in the heart of the capital.